Michelle Wegscheid

  • Warrenville, IL

  • Illinois-Urbana-Champaign, U. of (2013)

  • Neurosciences

  • David H. Gutmann, M.D., Ph.D.

  • Genetic risk factors for neurodevelopmental disorders: insights from hiPSC-cerebral organoids

  • wegscheidm@wustl.edu


During my PhD training, I pioneered a human-induced pluripotent stem cell (hiPSC)-derived forebrain cerebral organoid platform to study the genetic, molecular, and cellular determinants underlying nervous system dysfunction and disease heterogeneity in NF1. My projects made several conceptual advances in the field by establishing the germline NF1 gene mutation as an important factor underlying clinical variability in NF1 and revealing a new role for the CRLF3 gene in NF1-related neurodevelopmental defects, human neuronal differentiation, and autism risk assessment.

Graduate Publications:

Wegscheid ML, Anastasaki C, Hartigan KA, Cobb OM, Papke JB, Traber JN, Morris SM, Gutmann DH. 2021 Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis. Cell Rep, 36(1):109315.

Anastasaki C, Wegscheid ML, Hartigan K, Papke JB, Kopp ND, Chen J, Cobb O, Dougherty JD, Gutmann DH. 2020 Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations. Stem Cell Reports, 14(4):541-550.

Wegscheid ML, Anastasaki C, Gutmann DH. 2018 Human stem cell modeling in neurofibromatosis type 1 (NF1). Exp Neurol, 299(Pt B):270-280 (Review).

Last Updated: 8/23/2017 12:00:15 PM

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