Dillan Newbold

  • Boone, IA

  • Iowa, U. of (2014)

  • Neurosciences

  • Nico U.F. Dosenbach, M.D., Ph.D.

  • Maintenance of disused human brain circuits by spontaneous activity pulses

  • newbold@wustl.edu

Research

My work examines how the brain uses self-organized, spontaneous activity to maintain and refine its own circuits. Spontaneous activity is a crucial component of early brain development. Transient waves of spontaneous activity propagate through developing brain circuits and shape topological relationships between brain regions. Spontaneous brain activity is also present in adults, consumes the vast majority of the adult brain’s metabolic energy, and can be recorded non-invasively in healthy human volunteers using resting-state functional MRI (rs-fMRI). However, spontaneous activity in the adult brain—at least in the infra-slow (<0.1 Hz) frequencies measured with rs-fMRI—typically lacks the transient events seen in early development. We recently found that transient waves of spontaneous activity occur in adulthood in the setting of prolonged disuse. Constraining one upper extremity in a cast for two weeks caused marked disuse of anatomically specific motor circuits. Disused circuits exhibited large, transient pulses of spontaneous activity during casting. We suspect these pulses may be important for maintaining topographic relationships between brain regions in the absence of regular use. We are currently testing whether these pulses show coordinated wave-like propagation within multiple cortical and subcortical motor structures, which is a crucial feature that allows developmental spontaneous activity to refine brain topology. If present, this wave-like propagation of spontaneous activity pulses in the adult brain may help to prevent degradation of disused circuits, a finding that could be transformative for neurology and neurorehabilitation.

Graduate Publications:

Newbold DJ, Laumann TO, Hoyt CR, Hampton JM, Montez DF, Raut RV, Ortega M, Mitra A, Nielsen AN, Miller DB, Adeyemo B, Nguyen AL, Scheidter KM, Tanenbaum AB, Van AN, Marek S, Schlaggar BL, Carter AR, Greene DJ, Gordon EM, Raichle ME, Petersen SE, Snyder AZ, Dosenbach NUF. 2020 Plasticity and Spontaneous Activity Pulses in Disused Human Brain Circuits. Neuron, 107(3):580-589.e6.

Gordon EM*, Laumann TO*, Gilmore AW, Newbold DJ, Greene DJ, Berg JJ, Ortega M, Hoyt-Drazen C, Gratton C, Sun H, Hampton JM, Coalson RS, Nguyen AL, McDermott KB, Shimony JS, Snyder AZ, Schlaggar BL, Petersen SE, Nelson SM, Dosenbach NUF. 2017 Precision Functional Mapping of Individual Human Brains. Neuron, 95(4):791-807.e7.

Seo DO, Funderburk SC, Bhatti DL, Motard LE, LE, Newbold D, Girven KS, McCall JG, Krashes M, Sparta DR, Bruchas MR. 2016 A GABAergic Projection from the Centromedial Nuclei of the Amygdala to Ventromedial Prefrontal Cortex Modulates Reward Behavior. J Neurosci, 36(42):10831-10842.

Newbold DJ, Gordon EM, Laumann TO, Seider NA, Montez DF, Gross SJ, Zheng A, Nielsen AN, Hoyt CR, Hampton JM, Ortega M, Adeyemo B, Miller DB, Van AN, Marek S, Schlaggar BL, Carter AR, Kay BP, Greene DJ, Raichle ME, Petersen SE, Snyder AZ, Dosenbach NUF. Cingulo-opercular control network and disused motor circuits joined in standby mode. Proc Natl Acad Sci USA, 118(13):e2019128118.

Last Updated: 5/31/2018 3:59:56 PM

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