Jad Belle

  • Amman, Jordan

  • McGill U. (2011)

  • Molecular Genetics and Genomics

  • David G. DeNardo, Ph.D.

  • Stromal senescence in pancreatic cancer

  • j.belle@wustl.edu


Pancreatic ductal adenocarcinoma (PDAC) is the most lethal solid malignancy with a 5 year survival rate of 8%. Most patients are diagnosed at metastatic stages and treatments are largely ineffective. The refractory nature of PDAC has been attributed to its characteristic tumor microenvironment (TME) which comprises 70-80% of tumor mass. The TME is composed of an abundance of immunosuppressive myeloid cells and cancer-associated fibroblasts (CAFs) in a dense fibrotic matrix. Recent single cell transcriptomic studies have identified phenotypically heterogeneous CAF subsets but their specific functions remain unexplored. My project is focused on determining the role of a senescent CAF subset in PDAC biology and therapeutic resistance.

Last Updated: 8/21/2018 3:15:30 PM

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