Anna Trier

  • Sun Prairie, WI

  • Macalester College (2013)

  • Immunology

  • Brian S. Kim, M.D.

  • Immune regulation of chronic itch

  • atrier@wustl.edu

Research

Neuroimmune interactions at barrier surfaces play an integral role in promoting host survival by mediating neurophysiological processes like peristalsis, cough and itch. However, the cellular and molecular pathways that govern the complex interactions between the nervous and immune system remain poorly defined. Recently, our lab has identified a previously unrecognized mechanism by which the canonical type two cytokines IL-4 and IL-13 regulate chronic itch through direct neuronal signaling. This has led us to identify new therapeutic strategies for the treatment of multiple chronic itch disorders and the initiation of phase 2 clinical trials. The focus of my research project is to expand our understanding of neuroimmunology by identifying additional molecular pathways essential for the regulation of itch and other physiologic processes.

Graduate Publications:

Trier AM, Mack MR, Fredman A, Tamari M, Ver Heul AM, Zhao Y, Guo CJ, Avraham O, Ford ZK, Oetjen LK, Feng J, Dehner C, Coble D, Badic A, Joshita S, Kubo M, Gereau RW 4th, Alexander-Brett J, Cavalli V, Davidson S, Hu H, Liu Q, Kim BS. 2021 IL-33 Signaling in Sensory Neurons Promotes Dry Skin Itch. J Allergy Clin Immunol, (Sep 21):S0091-6749(21)01405-6.

Guo CJ, Mack MR, Oetjen LK, Trier AM, Council ML, Pavel AB, Guttman-Yassky E, Kim BS, Liu Q. 2020 Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation. J Invest Dermatol, 140(6):1244-1252.e4.

Trier AM, Mack MR, Kim BS. 2019 The Neuroimmune Axis in Skin Sensation, Inflammation, and Immunity. J Immunol, 202(10):2829-35.

Trier AM, Kim BS. 2018 Cytokine Modulation of Atopic Itch. Curr Opin Immunol, 54():7-12 (Review).

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, et al. 2017 Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell, 171(1):217-228.e13.

Last Updated: 9/14/2021 8:33:53 PM

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