Vincent Peng

Program: Immunology

Undergraduate university: Columbia University

Research summary
I am conducting my graduate thesis in the lab of Marco Colonna in the Department of Patholgy and Immunology. In a broad sense, our laboratory studies the innate immune system within the context of mice and humans. We have a strong focus on innate lymphoid cells, which are lymphocytes that lack specific antigen receptors. This class of innate immune cells remains poorly understood and may have dramatic impacts on human health and disease. My current work been focused on elucidating the regulation of innate lymphocytes. This work has taken the form of three distinct aims: 1) regulation by intrinsic metabolic pathways, 2) regulation by inhibitory factors in the tissue, and 3) regulation by epigenetic mechanisms such as DNA methylation.

Graduate publications
Peng V, Jaeger N. Colonna M. (2022). Innate Lymphoid Cells and Inflammatory Bowel Disease. In (eds.), Advances in Experimental Medicine and Biology (pp. 97-112). : Kluver.

Brioschi S, Wang WL, Peng V, Wang M, Shchukina I, Greenberg ZJ, Bando JK, Jaeger N, Czepielewski RS, Swain A, Mogilenko DA, Beatty WL, Bayguinov P, Fitzpatrick JAJ, Schuettpelz LG, Fronick CC, Smirnov I, Kipnis J, Shapiro VS, Wu GF, Gilfillan S, Cella M, Artyomov MN, Kleinstein SH, Colonna M. 2021 Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science, 373(6553):eabf9277.