Joshua Tobin
Program: Immunology
Current advisor: Megan A. Cooper, MD, PhD
Undergraduate university: Georgetown University
Research summary
I study inborn errors of immunity and am currently investigating a family with an inherited antibody deficiency associated with a tandem duplication on chromosome 14 intersecting the IGH locus. One gene in the duplication, JAG2, is upregulated more than 100-fold in B cells but not other immune cell subsets, which we hypothesize is due to enhancer hijacking of the IGH locus from the structural variant. Ongoing work includes investigating the genetic mechanism of JAG2 upregulation and the functional impact of JAG2 up regulation on B cell dysfunction.
Graduate publications
Mah-Som AY, Keppel MP, Tobin JM, Kolicheski A, Saucier N, Sexl V, French AR, Wagner JA, Fehniger TA, Cooper MA. 2021 Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion. Cell Rep, 35(9):109209.