Olivia Lazorik
Program: Unspecified
Current advisor:
Undergraduate university: Washington University
Research summary
Conventional MRI with diffusion weighted imaging (DWI) has several limitations, including confounding effects from stromal hyperplasia and inflammation. Diffusion Basis Spectral Imaging (DBSI), which deconvolutes diffusion signals into anisotropic and isotropic components, can more accurately depict underlying structural heterogeneity within a tumor image voxel compared to conventional DWI.
In my rotation project, I analyzed pre-radiotherapy treatment DBSI MR images acquired from cervical cancer patients enrolled in the U54 CRATR study. In collaboration with the Schwarz, Song, Ippolito, and Zhang labs, I registered DBSI images to corresponding PET scans and correlated DBSI metrics, serving as proxies for the tumor microenvironment, with metabolically active tumor regions.
Graduate publications