Suzanne Carpe Elias
Program: Unspecified
Current advisor:
Undergraduate university: Trinity College-Connecticut
Research summary
Lung ischemia-reperfusion injury (IRI), a major cause of early graft dysfunction after transplantation, is driven by recruitment of recipient neutrophils in response to signals from donor-resident lung cells. Resolvin D1 (RvD1), a Specialized Pro-Resolving Mediator, has been shown to attenuate IRI, but its cellular mechanisms remain unclear.
During my rotation in the Kreisel Lab, I joined ongoing efforts to test the hypothesis that RvD1 signals through the ALX/FRP2 receptor on donor-resident cells to suppress neutrophil-recruiting chemokines and adhesion molecules, thereby limiting neutrophil infiltration and tissue injury. We also used an allogeneic transplant mouse model to test whether RvD1 treatment early during transplant dampens adaptive alloimmunity.
Graduate publications