Ben Boros
Program: Neurosciences
Current advisor: Timothy M. Miller, MD, PhD
Undergraduate university: University of Alabama-Birmingham
Research summary
My thesis in the lab of Dr. Timothy Miller focused on understanding and manipulating non-coding regulatory elements to influence neurological diseases. We developed a novel approach using antisense oligonucleotides to influence RNA processing to promote gene augmentation. We applied this concept to amplify expression of genes linked with genetic haploinsufficiency, such as related to inherited forms of amyotrophic lateral sclerosis. In parallel, we studied epigenetic mechanisms that influence mouse vulnerability to chemical seizure induction. In this paradigm, we leveraged an epigenome-profiling technology Calling Cards to catalog transcription factor interactions that might confer protection against seizures. We then evaluated whether manipulating these interactions using pharmacological means could provide therapeutic benefit.
Graduate publications
Boros BD, Schoch KM, Kreple CJ, Miller TM. 2022 Antisense Oligonucleotides for the Study and Treatment of ALS. Neurotherapeutics, ():Epub ahead of print.