Carolyn Hsu
Program: Unspecified
Current advisor:
Undergraduate university: University of North Carolina-Chapel Hill
Research summary
CoQ is a highly hydrophobic molecule that is involved in many cellular processes including electron transport, antioxidation, acting as a cofactor for various mitochondrial enzymes and a role in inhibiting ferroptosis. However, little is known about its transport/distribution within the mitochondria and to other parts of the cell. Coq10p is a START domain protein that has been shown to bind CoQ and play a putative role as chaperoning the distribution of CoQ from its site of synthesis to its function at respiratory complexes. However, little is known about the mechanism through which it is acting in the cell. My rotation project focused on further characterizing the function of Coq10 in CoQ synthesis and transport through high-throughput lipidomics, proteomics and IP-MS.
Graduate publications