Grace Qi
Program: Unspecified
Current advisor:
Undergraduate university: Duke University
Research summary
ApoE allele has been shown to modulate amyloid burden in the brain, potentially by altering AB42 clearance through astrocytic receptors LDLR and LRP1 (among other mechanisms). In the current study, clearance of AB42 monomers, oligomers, and fibrils by fibroblasts differentially expressing LDLR or LRP1 was assessed in the presence of ApoE2, ApoE3, and ApoE4, and preliminary results suggest that ApoE3 and ApoE4 block uptake of AB42 via LRP1 but not LDLR.
Graduate publications