Jing Chen
Program: Immunology
Current advisor: Kenneth M. Murphy, MD, PhD
Undergraduate university: New York University
Research summary
Dendritic cells (DCs) functions to bridge innate and adaptive immunity by mediating the activity of various effector cells. The two branches of DCs consists of plasmacytoid DCs (pDCs) and classical DCs (cDCs), of which can be further subdivided into cDC1s and cDC2s. cDC1s are uniquely important in response against intracellular pathogens and tumors due to their ability to cross-present antigens. My work in the Murphy lab will seek to better understand DC development—specifically the molecular genetic circuitries and transcriptional requirements driving lineage-differentiation.
Graduate publications
Kim S, Chen J, Ou F, Liu TT, Jo S, Gillanders WE, Murphy TL, Murphy KM. 2024 Transcription factor C/EBPα is required for the development of Ly6Chi monocytes but not Ly6Clo monocytes. Proc Natl Acad Sci USA, 121(15):e2315659121.
Ferris ST, Liu T, Chen J, Ohara RA, Ou F, Wu R, Kim S, Murphy TL, Murphy KM. 2023 WDFY4 deficiency in NOD mice ameliorates autoimmune diabetes and insulitis. Proc Natl Acad Sci USA, 120(13):e2219956120.
Kim S, Chen J, Jo S, Ou F, Ferris ST, Liu TT, Ohara RA, Anderson DA, Wu R, Chen MY, Gillanders WE, Gillanders WE, Murphy TL, Murphy KM. 2023 IL-6 selectively suppresses cDC1 specification via C/EBPβ. J Exp Med, 220(10):e20221757.
Huang X, Ferris ST, Kim S, Choudhary MNK, Belk JA, Fan C, Qi Y, Sudan R, Xia Y, Desai P, Chen J, Ly N, Shi Q, Bagadia P, Liu T, Guilliams M, Egawa T, Colonna M, Diamond MS, Murphy TL, Satpathy AT, Wang T, Murphy KM. 2021 Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis. Immunity, 54(7):1417-1432.e7.