Jonathan Moran Sierra
Undergraduate university: University of Puerto Rico – Rio Piedras
Recent studies on Alzheimer’s have highlighted the role of microglia on disease pathogenesis. Previous work in the laboratory has identified several risk variants in TREM2, a microglia-related gene. By using TREM2 protein levels, additional microglia genes that take part of the TREM2 pathway can be identified, as well as their roles in modifying Alzheimer’s risk.
Proteomic profiles are made from Brain, CSF, and Plasma samples from over 3000 individuals to create predictive models and identify druggable targets.