Khai Nguyen
Program: Immunology
Current advisor: Marco Colonna, MD
Undergraduate university: Earlham College
Research summary
Single-cell genomics, particularly single-cell RNA sequencing (scRNA-seq), enables the comprehensive profiling of gene expression at the resolution of individual cells, uncovering cellular heterogeneity, identifying rare populations, and reconstructing developmental trajectories that are obscured in bulk analyses. My studies focused on the combination of complementary single-cell analyses and experimental approaches to dissect immune cell dynamics in the gut and brain.
Graduate publications
Brioschi S, Belk JA, Peng V, Molgora M, Rodrigues PF, Nguyen KM, Wang S, Du S, Wang WL, Grajales-Reyes GE, Ponce JM, Yuede CM, Li Q, Baer JM, DeNardo DG, Gilfillan S, Cella M, Satpathy AT, Colonna M. 2023 A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity, 56(5):1027-1045.e8.
Ver Heul A, Fredman A, Trier A, Tamari M, Nguyen K, Kim B. (2022). Type 2 inflammation drives transcriptional remodeling of itch-sensory neurons. J Allergy Clin Immunol., Abstract.
Wang S, Sudan R, Peng V, Zhou Y, Du S, Yuede CM, Lei T, Hou J, Cai Z, Cella M, Nguyen K, Poliani PL, Beatty WL, Chen Y, Cao S, Lin K, Rodrigues C, Ellebedy AH, Gilfillan S, Brown GD, Holtzman DM, Brioschi S, Colonna M. 2022 TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell, 185(22):4153-4169.e19.