Sasha Dmytrenko

Program: Immunology

Current advisor: Kory J. Lavine, MD, PhD

Undergraduate university: St. Olaf College

Research summary
My project in the Lavine Lab is focused on the effects of SARS-CoV-2 on the heart and cardiovascular system. Early in the pandemic of COVID-19, it became clear that some patients with severe symptoms present with cardiac symptoms. However, the extent and etiology of these manifestations were unknown. In my work, I am looking into cell types that are susceptible to SARS-CoV-2 in human heart, effects of the virus on these cells in vitro and developing a murine model of SARS-CoV-2 induced myocarditis

Graduate publications
Brumback BD, Dmytrenko O, Robinson AN, Bailey AL, Ma P, Liu J, Hicks SC, Ng S, Li G, Zhang DM, Lipovsky CE, Lin CY, Diamond MS, Lavine K, Rentschler SL. 2023 Human Cardiac Pericytes are Susceptible to SARS-CoV-2 Infection. JACC Basic Transl Sci, 8(2):109-120.

Ying B, Scheaffer SM, Whitener B, Liang CY, Dmytrenko O, Mackin S, Wu K, Lee D, Avena LE, Chong Z, Case JB, Ma L, Kim TTM, Sein CE, Woods A, Berrueta DM, Chang GY, Stewart-Jones G, Renzi I, Lai YT, Malinowski A, Carfi A, Elbashir SM, Edwards DK, Thackray LB, Diamond MS. 2022 Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice. Cell, 185(9):1572-1587.e11.

Dmytrenko O, Lavine KJ. 2022 Cardiovascular Tropism and Sequelae of SARS-CoV-2 Infection. Viruses, 14(6):1137.

Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ. 2021 Resident cardiac macrophages mediate adaptive myocardial remodeling. Immunity, 54(9):2072-2088.e7.

Bailey AL, Dmytrenko O, Greenberg L, Bredemeyer AL, Ma P, Liu J, Penna V, Winkler ES, Sviben S, Brooks E, Nair AP, Heck KA, Rali AS, Simpson L, Saririan M, Hobohm D, Stump WT, Fitzpatrick JA, Xie X, Zhang X, Shi PY, Hinson JT, Gi WT, Schmidt C, Leuschner F, Lin CY, Diamond MS, Greenberg MJ, Lavine KJ. 2021 SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis. JACC Basic Transl Sci, 6(4):331-345.


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