Rebecca Brady
Program: Neurosciences
Current advisor: Christopher D. Smyser, MD
Undergraduate university: Duke University
Research summary
My research broadly focuses on the relationships between perinatal risk factors, early brain development, and later psychiatric symptoms. As a member of the WUNDER lab, I examined whether living in a high crime neighborhood was related to infants’ brain function and toddlers’ externalizing symptoms, such as aggression and defiance. I also investigated whether maternal stress and parenting behaviors mediated these relationships. In a parallel line of work, I examined the development of callous-unemotional traits, which are defined by deficits in empathy, prosociality, and guilt and are present in a subset of children with externalizing symptoms. I investigated whether neonatal brain function was associated with preschool callous-unemotional traits in a prospective, longitudinal study. I also studied novel risk factors associated with early callous-unemotional traits, such as maternal emotional intelligence. Overall, my work aims to enhance our understanding of disruptive behaviors, identify targets for public health interventions, and spur further research into early identification and biologically informed treatments.
Graduate publications
Brady RG, Donohue MR, Waller R, Latham A, Ayala M, Smyser TA, Warner BB, Barch DM, Luby JL, Rogers CE, Smyser CD. 2024 Newborn Brain Function and Early Emerging Callous-Unemotional Traits. JAMA Psychiatry, 81(3):303-11.
Luby JL, Herzberg MP, Hoyniak C, Tillman R, Lean RE, Brady R, Triplett R, Alexopoulos D, Loseille D, Smyser T, Rogers CE, Warner B, Smyser CD, Barch DM. 2024 Basic Environmental Supports for Positive Brain and Cognitive Development in the First Year of Life. JAMA Pediatr, 178(5):465-72.
Donohue MR, Camacho MC, Drake JE, Schwarzlose RF, Brady RG, Hoyniak CP, Hennefield L, Wakschlag LS, Rogers CE, Barch DM, Luby J. 2024 Less attention to emotional faces is associated with low empathy and prosociality in 12-to 20-month old infants. Infancy, 29(2):113-36.
Herzberg MP, Nielsen AN, Brady R, Kaplan S, Alexopoulos D, Meyer D, Arora J, Miller JP, Smyser TA, Barch DM, Rogers CE, Warner BB, Smyser CD, Luby JL. 2024 Maternal prenatal social disadvantage and neonatal functional connectivity: Associations with psychopathology symptoms at age 12 months. Dev Psychol, ():Online ahead of print.
Brady RG, Leverett SD, Mueller L, Ruscitti M, Latham AR, Smyser TA, Gerstein ED, Warner BB, Barch DM, Luby JL, Rogers CE, Smyser CD. 2023 Neighborhood Crime and Externalizing Behavior in Toddlers: A Longitudinal Study With Neonatal fMRI and Parenting. J Am Acad Child Adolesc Psychiatry, ():Online ahead of print.
Brady RG, Rogers CE, Prochaska T, Kaplan S, Lean RE, Smyser TA, Shimony JS, Slavich GM, Warner BB, Barch DM, Luby JL, Smyser CD. 2022 The Effects of Prenatal Exposure to Neighborhood Crime on Neonatal Functional Connectivity. Biol Psychiatry, 92(2):139-48.
Brenner RG, Wheelock MD, Neil JJ, Smyser CD. 2022 Structural and functional connectivity in premature neonates. Semin Perinatol, 45(7):151473.
Brady RG, Donohue MR, Waller R, Tillman R, Gilbert KE, Whalen DJ, Rogers CE, Barch DM, Luby JL. 2022 Maternal emotional intelligence and negative parenting affect are independently associated with callous-unemotional traits in preschoolers. Eur Child Adolesc Psychiatry, ():.
Lean RE, Smyser CD, Brady RG, Triplett RL, Kaplan S, Kenley JK, Shimony JS, Smyser TA, Miller JP, Barch DM, Luby JL, Warner BB, Rogers CE. 2022 Prenatal exposure to maternal social disadvantage and psychosocial stress and neonatal white matter connectivity at birth. Proc Natl Acad Sci USA, 119(42):e2204135119.
Cyr PEP, Lean RE, Kenley JK, Kaplan S, Meyer DE, Neil JJ, Alexopoulos D, Brady RG, Shimony JS, Rodebaugh TL, Rogers CE, Smyser CD. 2022 Neonatal motor functional connectivity and motor outcomes at age two years in very preterm children with and without high-grade brain injury. Neuroimage Clin, 36():103260.
Barch DM, Hua X, Kandala S, Harms MP, Sanders A, Brady R, Tillman R, Luby JL. 2022 White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions. Depress Anxiety, 39(12):881-890.
Brenner RG, Smyser CD, Lean RE, Kenley JK, Smyser TA, Cyr PEP, Shimony JS, Barch DM, Rogers CE. 2021 Microstructure of the Dorsal Anterior Cingulum Bundle in Very Preterm Neonates Predicts the Preterm Behavioral Phenotype at 5 Years of Age. Biol Psychiatry, 89(5):433-42.