Sally Jee
Program: Unspecified
Current advisor:
Undergraduate university: Columbia University
Research summary
The dynorphin-kappa opioid receptor (KOR) system is implicated in reward seeking and motivational behaviors, thereby mediating the development of substance use disorders. Previous work from the Al-Hasani lab shows that activating dynorphin neurons in the nucleus accumbens (NAc) decreases fentanyl consumption in mice. Following up on previous results, we seek to investigate the role of the KOR system in fentanyl response by examining whether the decrease in fentanyl consumption is dependent on the KOR system or mediated by other pathways. To this end, we administered a KOR antagonist while stimulating dynorphin neurons in the NAc to observe whether fentanyl
consumption is restored.
Graduate publications