Sanjeev Gurshaney
Program: Unspecified
Current advisor: Rotating in the lab of Kodi S. Ravichandran, PhD
Undergraduate university: University of Central Florida
Research summary
PANX1 is a heptameric membrane channel known for releasing “eat-me” signals during apoptosis, which help to facilitate their clearance by phagocytes. In addition to this role, a 2021 study by Medina et al. demonstrated that PANX1 is also critical for Treg–Teff communication, highlighting its importance in immune regulation. In this rotation, I used a combination of biochemical, flow cytometric, and functional assays to characterize the kinetics and features associated with PANX1 channel opening in Jurkat T cells. Additionally, I began in vivo studies using a house dust mite (HDM) model of allergic inflammation to better understand the functional consequences of PANX1 modulation on immune responses and tissue homeostasis.
Graduate publications