Suyoun Choi
Program: Unspecified
Current advisor: Rotating in the lab of Jeffrey Magee, MD, PhD
Undergraduate university: Stanford University
Research summary
CAR cell therapies have the potential to improve numerous disease of the CNS, such as aggressive brain cancers and Alzheimer’s disease (AD). During this rotation, I worked collaboratively on a project to develop CAR DCs for glioblastoma, as well as CAR macrophages for AD. The CAR DC project, which is in collaboration with Albert Kim’s Lab, will test whether a CD40 signaling CAR DC injected into an SB28 tumor improves antitumor response and overall survival. The CAR macrophage project, which is in collaboration with Jin-Moo Lee’s lab, will test whether an amyloid targeting CAR macrophage, which also secretes a Tau repressor, successfully represses intracellular Tau production in neighboring cells within the CNS.
Graduate publications