Program: Computational and Systems Biology
Current advisor: Ting Wang, PhD
Undergraduate university: Bowdoin College
My current project aim to understand the regulation of transposable elements in cancer under p53. Previous studies have illustrated the correlation between the presence of p53 mutation and increased expression of transposable elements. However, there is a lack of systematic characterization for such phenomenon across all repeat elements and a lack of detailed understanding of the specific mechanism underlying such correlation. My project hopes to charactize this correlation in a genomic and epigenomic perspective. I also hope to unveil some elements involved in this regulatory pathway.
DeSouza PA, Qu X, Chen H, Patel B, Maher CA, Kim AH. 2021 Long, Noncoding RNA Dysregulation in Glioblastoma. Cancers (Basel), 13(7):1604..
Mahlokozera T, Patel B, Chen H, Desouza P, Qu X, Mao DD, Hafez D, Yang W, Taiwo R, Paturu M, Salehi A, Gujar AD, Dunn GP, Mosammaparast N, Petti AA, Yano H, Kim AH. 2021 Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. Nat Commun, 12(1):6321.